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During the evolution of Cyanobacteria and Proteobacteria, GSH-dependent ROS detoxification systems incorporated enzymes that play crucial roles in these mechanisms and use GSH as a cofactor, such as GSH peroxidases, GSH reductases, glutaredoxins, and GSH-S-transferases [41]

The results of one study showed that MSCs may have detrimental effects on the lung environment, inducing high levels of both IL-6 and fibronectin (FN) and low antioxidant capacity

The key remains: Balance

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Methylglyoxal impairs energy production and the anti-oxidative protective effects, thereby contributing to the enhanced PS exposure of circulating erythrocytes and ultimately resulting in anemia and microcirculatory disequilibrium [321]

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